PubMed COVID-19 Clinical Care

SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates

Thursday, January 18, 2024 - 4:00 AM

We examined the histopathological changes in the olfactory mucosa of cynomolgus and rhesus macaque models of SARS-CoV-2 infection. SARS-CoV-2 infection induced severe inflammatory changes in the olfactory mucosa. A major histocompatibility complex

Leading primary care under the weight of COVID-19: how leadership was enacted in six australian general practices during 2020

Thursday, January 18, 2024 - 4:00 AM

CONCLUSION: This study demonstrates the importance of collaborative leadership during crises while highlighting areas for better preparedness. Promoting interdisciplinary communication and implementing formal leadership training in crisis management

COVID-19 impairs oxygen delivery by altering red blood cell hematological, hemorheological, and oxygen transport properties

Thursday, January 18, 2024 - 4:00 AM

Introduction: Coronavirus disease 2019 (COVID-19) is characterized by impaired oxygen (O(2)) homeostasis, including O(2) sensing, uptake, transport/delivery, and consumption. Red blood cells (RBCs) are central to maintaining O(2) homeostasis and

Retraction: PSCNN: PatchShuffle convolutional neural network for COVID-19 explainable diagnosis

Thursday, January 18, 2024 - 4:00 AM

[This retracts the article DOI: 10.3389/fpubh.2021.768278.].

Impact of the COVID-19 Pandemic on Inpatient Utilization for Acute Neurologic Disease

Thursday, January 18, 2024 - 4:00 AM

Background and Objective: The initial months of the Corona Virus 2019 (COVID-19) pandemic resulted in decreased hospitalizations. We aimed to describe differences in hospitalizations and related procedures across neurologic disease. Methods: In our

New-Onset Psoriatic Arthritis Following COVID-19 mRNA Vaccination in a Psoriatic Patient Under Anti-tumor Necrosis Factor Alpha Biologic Treatment: What Now?

Thursday, January 18, 2024 - 4:00 AM

During the COVID-19 pandemic, anti-SARS-CoV-2 vaccines were quickly developed and administered to the population worldwide. As is expected with new vaccine products, adverse reactions following immunization have been reported, namely, the development

Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment

Thursday, January 18, 2024 - 4:00 AM

The SARS-CoV-2 virus activates maternal and placental immune responses, which in the setting of other infections occurring during pregnancy are known to impact fetal brain development. The effects of maternal immune activation on neurodevelopment are

De-stabilizing innate immunity in COVID-19: effects of its own positive feedback and erratic viraemia on the alternative pathway of complement

Thursday, January 18, 2024 - 4:00 AM

Complement provides powerful, fast responses in the human circulation to SARS-CoV-2 (COVID-19 virus) infection of the lower respiratory tract. COVID-19 effects were investigated in a revised human in silico Mass Action model of complement's

The impact of body mass index on long-term survival after ICU admission due to COVID-19: A retrospective multicentre study

Thursday, January 18, 2024 - 4:00 AM

CONCLUSIONS: The obesity paradox appears to exist beyond hospital discharge in critically ill patients with COVID-19 admitted in Australian and New Zealand ICUs. A BMI ≥40 kg/m² was associated with a higher survival time of up to two years.

Targeting protein-protein interaction interfaces with anti-viral N protein inhibitor in SARS-CoV-2

Thursday, January 18, 2024 - 4:00 AM

Coronaviruses not only pose significant global public health threats but also cause extensive damage to livestock-based industries. Previous studies have shown that 5-benzyloxygramine (P3) targets the Middle East respiratory syndrome coronavirus