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PubMed COVID-19 Clinical Care

8771 - 8780 of 50647 results found

BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease

Date
Thursday, February 08, 2024 - 4:00 AM
Description
Numerous organic molecules are known to inhibit the main protease (M^(Pro)) of SARS-CoV-2, the pathogen of Coronavirus Disease 2019 (COVID-19). Guided by previous research on zinc-ligand inhibitors of M^(Pro) and zinc-dependent histone deacetylases

Addressing Vaccine Hesitancy: A Nursing Perspective

Date
Thursday, February 08, 2024 - 4:00 AM
Description
CONCLUSIONS: Vaccination uptake is impacted by misinformation and disinformation. Vaccine hesitancy is impacting the uptake of other routine immunizations putting Americans at risk. Regardless of vaccination policies, health care professionals must

Robust expansion of phylogeny for fast-growing genome sequence data

Date
Thursday, February 08, 2024 - 4:00 AM
Description
Massive sequencing of SARS-CoV-2 genomes has urged novel methods that employ existing phylogenies to add new samples efficiently instead of de novo inference. 'TIPars' was developed for such challenge integrating parsimony analysis with pre-computed

Hyaluronan deposition during COVID-19 - helpful or harmful?

Date
Thursday, February 08, 2024 - 4:00 AM
Description
Hyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated